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The Certara "Privacy" link below has a new URL. The methods used in developing and solving the model could be used for similar toxicokinetic and pharmacokinetic studies of other animals.Note: the launching of a new Certara website makes it necessary to publish a new versions of these Terms and Conditions for Certara University. The T-2 elimination rates in the hepatopancreas and intestine were similar and quite high while that in the muscle was very low. The hepatopancreas and intestine belonged to the fast and muscle to the slow metabolizing compartments, respectively, while the hemolymph had no capacity to metabolize T-2. administration, T-2 was rapidly absorbed into the hemolymph and distributed into shrimp organs. It was revealed through the model that after i.m. The model had a good fit with the experimental data. The toxicokinetic model was solved by the blindfold particle swarm optimization algorithm, and the values for the model equation parameters were obtained by applying the experimental data of T-2 concentrations in shrimp. The three compartments were central (the hemolymph), slow metabolizing and fast metabolizing compartments to account for the varying ADME rates of T-2 in different shrimp organs. Here, we describe the development of a three-compartment toxicokinetic model for the absorption, distribution, metabolism and elimination (ADME) of T-2 in shrimp. Tricothecenes-2 toxin (T-2) is a major mycotoxin that is widely distributed in aquatic feeds and poses a huge challenge to the aquatic industry, but there is scant information on the toxicokinetics of T-2 in aquatic animals.